Wetherspoons’ Velvet Coaster, named after an early ride at the Pleasure Beach, threw open the doors to welcome the first customers to the £3.86m purpose-built superpub.
Blackpool Mayor Coun Val Haynes said she was impressed with the quality of build of the pub.
She said: “It is amazing, absolutely fantastic.
“This is exactly the sort of investment Blackpool needs.
“We wish Wetherspoons every success. It is a brilliant asset to the resort and the firm has brought a tremendous amount of investment to Blackpool over the years.”
The pub will be open from 8am until midnight seven days a week, which means a large number of staff will be needed to cover shifts behind the bar and in the kitchen, resulting in bumper job opportunities.
Pub general manager Becki White said: “Learning everyone’s name is quite a challenge! This must be the biggest Wetherspoons pub in the country, and its design is amazing and very exciting to be opening.
“We will be having beers from the Lytham and Phoenix breweries.
“We do food all day from breakfast right up until 10pm and children are welcome until that time.”
Gail Marsden and her partner Phil Moores, on a short break from Huddersfield, said they were amazed by the size of the pub. Gail said: “I have never seen a pub so big, but at the same time it is quite cosy with all the different sections and the open fire.”
Phil said: “We are here for breakfast and then we will come back tonight. I love the Blackpool theme in the decoration and the seating areas on the roof are great.”